Trisevgeni Rapakoulia, a Ph.D. candidate under the supervision of Professor Xin Gao defended her Ph.D. thesis "Computational Analysis of Transcriptional Regulation after Single and Multiple Drug Administration".
Transcriptomics is the
large-scale study of RNA molecules produced by the genome, in single cells or
population of cells using high-throughput methods. With the advances in
transcriptomic analysis, the monitoring of genome-wide gene expression provides
a powerful approach for determining the action of drugs. In this thesis, we
analyzed the transcriptional responses of cells treated with drugs either alone
or in combinations to explore their effects in two different applications:
breast cancer therapy and cell conversion.
Trisevgeni Rapakoulia is a Ph.D. candidate in Xin Gao's group at King Abdullah University of Science and Technology (KAUST) thuwal, Saudi Arabia. She holds her Master's Degree in Informatics for Life Sciences, Medical School, University of Patras-Greece Specialization: Bioinformatics, 2013, and Bachelor's Degree in Computer Engineering & Informatics, University of Patras-Greece, 2010. Her research interests broadly concerns Bioinformtics, Machine Learning, and Drug Combinations.