Population genetics of non-genetic traits: a role of stochasticity in gene expression profiles

K. Mineta, T. Matsumoto, N. Osada, H. Araki
GENE, 562, 16-21, (2015)

Population genetics of non-genetic traits: a role of stochasticity in gene expression profiles

Keywords

Stochasticity, Gene expression, Fitness, Effective population size, Selection

Abstract

The role of stochasticity in evolutionary genetics has long been debated. To date, however, the potential roles of non-genetic traits in evolutionary processes have been largely neglected. In molecular biology, growing evidence suggests that stochasticity in gene expression (SGE) is common and that SGE has major impacts on phenotypes and fitness. Here, we provide a general overview of the potential effects of SGE on population genetic parameters, arguing that SGE can indeed have a profound effect on evolutionary processes. Our analyses suggest that SGE potentially alters the fate of mutations by influencing effective population size and fixation probability. In addition, a genetic control of SGE magnitude could evolve under certain conditions, if the fitness of the less-fit individual increases due to SGE and environmental fluctuation. Although empirical evidence for our arguments is yet to come, methodological developments for precisely measuring SGE in living organisms will further advance our understanding of SGE-driven evolution.

Code

DOI: 10.1016/j.gene.2015.03.011

Sources

Website PDF

See all publications 2015