An atlas of combinatorial transcriptional regulation in mouse and man
T. Ravasi, H. Suzuki, C.V. Cannistraci, S. Katayama, V.B. Bajic, K. Tan, A. Akalin, S. Schmeier, M. Kanamori-Katayama, N. Bertin, P. Carninci, C.O. Daub, A.R. Forrest, J. Gough, S. Grimmond, J.H. Han, T. Hashimoto, W. Hide, O. Hofmann, A. Kamburov, M. Kau
Cell, 140(5): 744-752, (2010)
Combinatorial interactions among transcription factors are critical to
directing tissue-specific gene expression. To build a global atlas of
these combinations, we have screened for physical interactions among the
majority of human and mouse DNA-binding transcription factors (TFs).
The complete networks contain 762 human and 877 mouse interactions.
Analysis of the networks reveals that highly connected TFs are broadly
expressed across tissues, and that roughly half of the measured
interactions are conserved between mouse and human. The data highlight
the importance of TF combinations for determining cell fate, and they
lead to the identification of a SMAD3/FLI1 complex expressed during
development of immunity. The availability of large TF combinatorial
networks in both human and mouse will provide many opportunities to
study gene regulation, tissue differentiation, and mammalian evolution.
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