In this talk, I will introduce our recent efforts on developing novel computational models in the field of biological imaging. I will start with the examples in electron tomography, for which I will introduce a robust and efficient scheme for fiducial marker tracking, and then describe a novel constrained reconstruction model towards higher resolution sub-tomogram averaging. I will then show our work on developing deep learning methods for super-resolution fluorescence microscopy.
Dr. Xin Gao is a professor of computer science in CEMSE Division at KAUST. He is also the Acting Associate Director of the Computational Bioscience Research Center (CBRC), Deputy Director of the Smart Health Initiative (SHI), and the Lead of the Structural and Functional Bioinformatics Group at KAUST. Prior to joining KAUST, he was a Lane Fellow at Lane Center for Computational Biology in School of Computer Science at Carnegie Mellon University. He earned his bachelor degree in Computer Science in 2004 from Tsinghua University and his Ph.D. degree in Computer Science in 2009 from University of Waterloo.
Dr. Gao's research interest lies at the intersection between computer science and biology. In the field of computer science, he is interested in developing machine learning theories and methodologies related to deep learning, probabilistic graphical models, kernel methods and matrix factorization. In the field of bioinformatics, his group works on building computational models, developing machine learning techniques, and designing efficient and effective algorithms to tackle key open problems along the path from biological sequence analysis, to 3D structure determination, to function annotation, to understanding and controlling molecular behaviors in complex biological networks, and, recently, to biomedicine and healthcare.
He has published more than 230 papers in the fields of bioinformatics and machine learning. He is the associate editor of Genomics, Proteomics & Bioinformatics, BMC Bioinformatics, Journal of Bioinformatics and Computational Biology, and Quantitative Biology, and the guest editor-in-chief of IEEE/ACM Transactions on Computational Biology and Bioinformatics, Methods, and Frontiers in Molecular Bioscience.