Prof. Arold's research is dedicated to elucidating the molecular basis of the function and (de)regulation of proteins central to cellular key signaling networks in bacteria, plants, and animals. His investigations are based on an integrated structural biology approach that combines functional and structural data from multiple sources (small angle x-ray scattering, X-ray crystallography, NMR, EM, computational methods, biochemistry, ligand binding assays and functional analyses). Results are translated to engineer molecules with desired properties (e.g. reporters or inhibitors). Structural biology approaches are also used to enhance computational methods for functional annotation of genes (system-wide or focused).