Waterman holds an Endowed Associates Chair at USC. He came to USC in
1982 after positions at Los Alamos National Laboratory and Idaho State
University. He has a bachelor’s degree in Mathematics from Oregon State
University, and a PhD in Statistics and Probability from Michigan State
University. He has held visiting positions at the University of Hawaii
(1979-80), the University of California at San Francisco (1982), Mt.
Sinai Medical School (1988), Chalmers University (2000), and in
2000-2001 he held the Aisenstadt Chair at University of Montreal.
Waterman was named a Guggenheim Fellow (1995). He is an elected member
of the American Academy of Arts and Sciences (1995), the National
Academy of Sciences (2001) and the National Academy of Engineering
(2012). Also he is a elected Fellow of the American Association for the
Advancement of Science (1990), Institute of Mathematical Statistics
(1991), Society of Industrial and Applied Mathematics (2009) and
International Society of Computational Biology (2009). In fall 2000 he
became the first Fellow of Celera Genomics. Waterman received a Gairdner
Foundation International Award (2002), the Friendship Award from the
Chinese government (2013) and the Dan David Prize (2015). He is an
elected Foreign Member of the French Académie des Sciences (2005) and
the Chinese Academy of Sciences (2013). He received Doctor Philosophiae
Honors Causia from Tel Aviv University (2011) and Southern Denmark
During 2003-2008, Professor Waterman
held a 5-year term as Faculty Master of Parkside International Residence
College at USC. PIRC is a residential college that is home to over 600
undergraduates and serves as a center for internationally oriented
cultural, academic and social events.
From May 2008 to May 2014,
in addition to his USC appointment Michael Waterman became Chair
Professor at Tsinghua University in Beijing. He led a team of
distinguished scientists which collectively worked to enhance Tsinghua's
programs in bioinformatics and computational biology. Currently he is
Cao Xingcheng Chair Professor at Tsinghua University and Distinguished
Professor at Fudan University in Shanghai.
Michael Waterman is a
founding editor of Journal of Computational Biology and is on the
editorial board of several journals. He is the author of Introduction to
Computational Biology: Maps, Sequences and Genomes and is a co-author
of the text Computational Genome Analysis: An Introduction. Also with
Istrail and Pevzner in 1997 he began the international conference
Research in Computational Biology (RECOMB).
works in the area of Computational Biology and Bioinformatics,
concentrating on the creation and application of mathematics, statistics
and computer science to molecular biology, particularly to DNA, RNA and
protein sequence data. He is the co-developer of the Smith-Waterman
algorithm for sequence comparison and of the Lander-Waterman formula for
physical mapping. His paper with Idury in 1995 introduced the use of
Eulerian and De Bruijn graphs for sequence assembly.
Issues of Sequence Comparison: Analysis by Position and Analysis by Pattern
Comparison of DNA and protein sequences is often done by calculation of an optimal alignment between two sequences. This talk will briefly survey statistical issues for global and local alignment, including Smith-Waterman and BLAST. In the last few years analysis by pattern or word counts has become important. A careful analysis of the relevant count summaries is crucial to increasing the statistical power of this approach.