Adeeb Noor is an assistant professor in the faculty of
computing and information technology at King Abdulaziz University, Jeddah and
the IT director of King Abdulaziz University Hospital. He received his PhD in
bioinformatics from the University of Colorado at Boulder in 2015, where
he did his PhD under the supervision of Prof James Martin and Michel Dumontier.
His work areas include data integration in bioinformatics, drug mechanisms,
pharmacovigilance, and precision medicine.
Dr. Noor is currently working on mining patient data at King
Abdulaziz University Hospital to improve the healthcare. He is also a part of a
project that applies next-generation DNA sequencing (NGS) technique to study
rare diseases, adverse drug events and pharmacogenomics.
From Big Data to Prescription: A Semantic Web
Approach to Improve Medication Safety
Adverse drug events (ADEs), which
often are caused by drug interactions, may result in morbidity, mortality, and
increased healthcare expenditures. As the role of drug therapy continues
to expand and polypharmacy becomes more common, the prevalence of ADEs also
increases, potentially limiting the therapeutic benefits of medication therapy.
Indeed, identifying ADEs before
drugs reach the market has been extremely challenging due to the limited
availability of clinical studies, shortcomings within study designs, limited
accessibility of drug interaction information due to storage in disparate
sources, and omissions in interactions reporting within information sources,
especially regarding their mechanisms and clinical significance.
In this talk, I will describe an integrative
approach to medication safety using semantic web technologies. Semantic Web is
not only useful for domain analysis, but can also be used to inform strategies
for ADEs prevention. I will show how this approach can be useful for clinicians
and researchers to gain some foresight into the likelihoods and causes of ADEs.