• Digital-Health-Conference-2020

Invited SpeakersProfile Details

Prof. Wei Chen
Prof. Wei Chen Dr. Chen obtained his Ph.D. degree from Max-Planck-Institute for Molecular Genetics.

Biography

Dr. Chen obtained his Ph.D. degree from Max-Planck-Institute for Molecular Genetics, Berlin in 2006. He was trained in human molecular genetics and bioinformatics. Between 2007 and 2008, he stayed at the same institute and led a research group. During this time, His group developed one of the first experimental and data analysis pipelines for Illumina/Solexa sequencing. At 2009, he moved to the newly established Berlin Institute for Medical Systems Biology at Max-Delbrueck-Center for Molecular Medicine (MDC), Berlin, where he led Laboratory of Functional Genomics and Systems Biology. At 2015, he was appointed as a full (W3) professor at MDC jointly with Charité - Universitätsmedizin Berlin. At 2016, he was awarded Thousand Talent Program from Chinese government and moved back to SUSTech at Shenzhen, China. Apart from being the chair of department of biology, he is now also serving as vice-dean of SUSTech Academy of Advanced Interdisciplinary Research, an organization promoting the collaborative studies between different departments at SUSTech. His lab has been developing various genomics assays based on the novel sequencing technology. Using the functional genomics and systems biology approach, his lab has been dissecting the molecular mechanisms underlying gene regulations at different levels, and addressing the pattern of gene regulatory changes in evolution and their role in causing human diseases.

All sessions by Prof. Wei Chen

  • Day 2Tuesday, January 21st
Session 4 : Digital Health and Biotechnology (Chair Stefan Arold)
1:50 pm

Gene regulation and dysregulation in human diseases

"DNA makes RNA makes protein." To meet the demands of complex organism development and the appropriate response to environmental stimuli, every step in these processes needs to be finely regulated. Dysregulation could result in pathological conditions. Our lab is interested in quantitative understanding of the molecular mechanism underlying different layers of gene regulation and their dysregulation in human diseases including cancer.

In this talk, I will present our recent study of transcriptional and post-transcriptional dysregulation during EMT process using colorectal cancer cell as a model. Here, by integrating a variety of genomics, transcriptomics and epigenomics data, we identified a number of metastasis-related transcription factors that were transcriptionally or post-transcriptionally dysregulated during EMT process.

Their effects could be validated by using in vitro and in vivo assays. Further functional analysis of their target genes revealed novel pathways involved in EMT process. Finally, indicated by patient survival data of various cancer, these transcription factors may serve as markers with high prognostic potential.

Building 19, Hall 1 13:50 - 14:15 Details